These DUBs belong to six families: the ubiquitin-specific protease (USP), ubiquitin C-terminal hydrolase (UCH), ovarian tumour protease (OTU), Josephin (JOS), JAB1/MPN/MOV34 (JAMM) families [4] or the newly discovered motif-interacting with Ub (MIU)-containing novel DUB (MINDY) family [5]. Here, ATXN3 is linked to neoplasm.