In spite of the phenotypic correction of FA cells edited with the EGFP/PGK‐FANCA donor, these cells did not show the expected EGFP‐expression, suggesting the low activity of the AAVS1 regulatory sequences in FA LCLs, which contrasts with our results in FA‐A fibroblasts edited with the same construct (Rio et al, 2014). The gene discussed is FANCA; the disease is Friedreich ataxia.