This may also indicate that, under some circumstances, increased supply could override physiological control, which may be relevant for pathophysiological conditions in which a large amount of extracellular Glut is acutely available, as may occur in epilepsy or Alzheimer's disease (Talantova et al., 2013, Soukupova et al., 2015). This evidence concerns the gene SLC2A1 and early-onset autosomal dominant Alzheimer disease.