This may also indicate that, under some circumstances, increased supply could override physiological control, which may be relevant for pathophysiological conditions in which a large amount of extracellular Glut is acutely available, as may occur in epilepsy or Alzheimer's disease (Talantova et al., 2013, Soukupova et al., 2015). The gene discussed is SLC2A1; the disease is epilepsy.