2015). We did find a trend for decreased PON‐1 activity, a protective antioxidant enzyme that is associated with HDL, in tobacco cigarette and e‐cigarette users compared to controls. This inverse relationship is consistent with our prior report in young women, in whom we found a correlation between decreased PON‐1 activity and increased number of tobacco cigarettes smoked (Ramanathan et al. 2014). Decreased PON‐1 activity has been found to be an independent predictor of premature coronary artery disease in patients younger than 45 years (Sarkar et al. 2006). The gene discussed is PON1; the disease is coronary artery disorder.