We found that OS was independently associated with age (HR = 1.356, 95% CI 1.059–1.735, P = 0.026), Borrmann classification (HR = 1.521, 95% CI 1.279–1.810, P < 0.001), TNM stage (HR = 2.081, 95% CI 1.772–2.443, P < 0.001), CEA (HR = 1.431, 95% CI 1.006–2.035, P = 0.027), and SII (HR = 1.551, 95% CI 1.211–1.987, P = 0.015), whereas tumor location, NLR, and PLR were not independent prognostic factors. Here, CEACAM5 is linked to neoplasm.