Since ApoE-null mice are a commonly used model of atherosclerosis and micro-infarcts have been suggested as causes for myofiber damage in DMD, we investigated whether loss of dystrophin expression in the vasculature of ApoE mice had any effect on atherosclerosis development—a potential confounding factor that could rationalize increased myofiber damage in mdx-ApoE mice. The gene discussed is DMD; the disease is Duchenne muscular dystrophy.