Similarly, hyperlipidemia did not affect mdx-associated pathology in the diaphragm muscle (Additional file 7: Figure S6A): both mdx and mdx-ApoE mice on a Western diet showed significant levels of fibrosis and myofiber damage with similar decreases in healthy myofiber area at 4 and 7 months on Western diet (Additional file 7: Figure S6B–E). This evidence concerns the gene APOE and hyperlipidemia.