The increase in Evan’s blue dye leak from the vasculature in mdx and mdx-ApoE mice supports the idea that there is inherent vascular dysfunction associated with dystrophin-deficiency and that, in the context of hyperlipidemia, this may facilitate circulating lipids to infiltrate the muscle tissue and to cause muscle damage or affect muscle repair and remodeling. This evidence concerns the gene APOE and hyperlipidemia.