In particular, the following elements were omitted: (i) cost-benefit evaluation of statin therapy; (ii) additional consideration of other factors such as apolipoprotein B, glomerular filtration rate, microalbuminuria, ankle-brachial index and carotid intima-media thickness; (iii) subgroup analysis such as racial, regional and gender differences; and (iv) analysis of secondary prevention in patients with established ASCVD. This evidence concerns the gene APOB and atherosclerosis.