Initial diagnoses were SCCHN (n = 21 [39%]), ESCC (n = 15 [28%]), HER2-overexpressing breast cancer (n = 10 [19%]), and gastric cancer (n = 8 [15%]); most patients (91%) had ≥ stage IV disease at study entry (Table 1). This evidence concerns the gene ERBB2 and gastric cancer.