CXCL2 and infection: The identified host DEGs were mainly up-regulated and activated many immune signaling pathways, such as the TLR, NLR, RLR, RIG-I, BCR, and TCR signaling pathways, and caused up-regulation of Csf2, Cxcl2, Il6, Ccl4, Il1b, Il23α, Il1α, Il10, Il17f, Il17a, Tnf, and Ifng, among other cytokines, leading to an anti-infection cytokine cascade and causing lung damage.