According to the microarray data analysis (2.0-fold up- or down-regulated and p<0.05) (the data have been deposited in the GEO: GSE64633), the expression levels of INTS6 were dramatically down-regulated in HCC vs. matched normal liver tissues (p = 0.015) (Fig. 1a, b). The gene discussed is INTS6; the disease is hepatocellular carcinoma.