Transcriptional profile in normal lung tissue and urethane-induced tumors from wild-type and Nfe2l2 knockout mice showed induced expression of genes involved in cell growth and proliferation, Wnt/β-catenin signaling, and Notch signaling in an Nrf2-dependent manner, suggesting a possible mechanism for the contribution of Nrf2 to cancer progression (142). This evidence concerns the gene NFE2L2 and cancer.