NFE2L2 and neoplasm: Oncogenic Kras and B-Raf, Myc (30), the phosphoinositide 3-kinase (PI3K)-Akt pathway (107), and the Notch signaling pathway (173) have also been reported to augment Nfe2l2 transcription, thus suggesting a possible mechanism for the increased expression of Nrf2 in tumor cells.