ERBB2 and cancer: Seidman et al. reported the final results of randomized phase III trial of weekly compared with every-3-weeks paclitaxel for metastatic breast cancer, with trastuzumab for all HER-2 overexpressors and random assignment to trastuzumab or not in HER-2 nonoverexpressors (Cancer and Leukemia Group B protocol 9840).