In contrast, on other cells such as human chondrocytes adiponectin has a pro-inflammatory role inducing increased levels of NOS2, IL-6, metalloproteinases 3 and 9 and also enhances monocyte chemoattractant protein-1 (MCP-1) production, whereas in synovial fibroblasts adiponectin induces IL-6, MMP-1 and IL-8 production, in addition high levels of adiponectin have been correlated with the severity and joint destruction in RA patients [8]. This evidence concerns the gene IL6 and rheumatoid arthritis.