Rovin et al., identified increased plasma levels of adiponectin in SLE with renal involvement in comparison with SLE without renal flare, but these levels were not significant in the multivariate analysis and the association of adiponectin levels and renal involvement was found only in the univariate analysis, and did not remain after adjusting for confounders [18]. The gene discussed is ADIPOQ; the disease is systemic lupus erythematosus.