PHOX2B and central hypoventilation syndrome, congenital: Congenital central hypoventilation syndrome (CCHS), previously known as Ondine’s curse, is an autosomal dominant disorder that results from a heterozygous mutation in the paired-like homeobox 2B gene (PHOX2B) on chromosome 4p13 in the majority of patients (OMIM #209880, #603851).