Angelman syndrome (AS) (OMIM # 105830) is caused by the absence or non-functioning of the maternal ubiquitin-protein ligase E3A gene (UBE3A, OMIM #601623) on chromosome 15q11.2-q13 and occurs in 1 in 12,000–20,000 individuals, affecting males and females equally [23,24,25]. Here, UBE3A is linked to Angelman syndrome.