Combination therapies involving anti-cancer agents such as tamoxifen, bortezomib, 5-FU, cisplatin, imatinib, rapamycin, and hormone therapy with autophagy inhibitors like 3-methyladenine (3-MA), BAF (bafilomycin A), CQ, or the knockdown of autophagy signaling mediators (ATG5, ATG6, and ATG7) by siRNA significantly inhibits cancer cell growth and metastasis in breast, colorectal, prostate, skin, and gastric cancers [66,67,68,69]. This evidence concerns the gene ATG5 and cancer.