ALK-positive ALCL also presents with more advanced stage III/IV disease in up to 60% of cases [44,45], though its prognosis with multi-agent chemotherapy tends to fare better with 5-year survival rates ranging between 71–100% compared to 15–45% for ALK-negative ALCL [35,44,46,47,48,49]. Here, ALK is linked to anaplastic large cell lymphoma.