This article will explore the role of ALK mutations in cutaneous malignancies, including its well-known association with systemic and primary cutaneous ALCL, as well as its emerging role in other cutaneous malignancies, such as melanoma, spitzoid melanocytic neoplasms, epithelioid fibrous histiocytomas, Merkel cell carcinoma, and basal cell carcinoma. This evidence concerns the gene ALK and Merkel cell skin cancer.