NRAS and melanoma: In this study ALK was identified as the most frequently mutated gene among “pan-negative” melanomas, or melanomas without recurrent mutations in five known driver genes BRAF, NRAS, KIT, GNAQ, and GNA11. Of the ALK mutations identified, four were predicted to have a medium to high impact on protein function by the Mutation Assessor, though whether or not they could result in increased ALK activity was not studied [100].