SEPT2 (NEDD5), SEPT1 (DIFF6), and SEPT4 (H5) have been found to be associated with Alzheimer-specific neuro fibrillar tangles by use of immunocytochemistry and immunoelectron microscopy [15], while co-immunoprecipitation assay revealed SEPT5 (CDCRel-1) interact with Parkin, a pathogenic protein in Parkinson’s Disease [16]. This evidence concerns the gene SEPTIN5 and Parkinson disease.