Significant associations with VDR polymorphisms have been reported for prostate (Fok1, Bsm1, and Taq1), breast (Fok1, Bsm1, and Apa1), colon-rectum (Fok1, Bsm1, and Taq1), and skin (Fok1, Bsm1, and Taq1) cancers [82]. The gene discussed is VDR; the disease is cancer.