COL27A1 and Steel syndrome: Indeed, although COL27A1 was first implicated as the Steel syndrome disease locus in an extended family from Puerto Rico recently (Chang et al., 2015), other variants in COL27A1 have since been linked to Steel syndrome in Indian (Kotabagi et al., 2017) and Emerati (Gariballa et al., 2017) families revealing additional clinical features of the disease such as hearing loss.