This shows that peripheral and systemic AChE inhibitors characterize similar effectiveness in the prevention of inflammatory dependent distribution of GnRH/LH secretion and suggests that pivotal mechanism in the pathophysiology of neuroendocrine disorders occurring during an immune challenge is the elevation of peripheral proinflammatory cytokines concentration to the level necessary to transition of the information about the ongoing peripheral inflammation into the brain. Here, ACHE is linked to neuroendocrine disorder.