Sitagliptin improved endothelial function [39] and attenuated cardiac remodeling without affecting systolic function after myocardial infarction [40] while, in normoglycemic rats with induced myocardial infarction, sitagliptin prevented fatal arrhythmias by attenuating GIP-dependent resistin signaling [41] and in a PKA-dependent pathway [42]. This evidence concerns the gene RETN and myocardial infarction.