In another report, 21 children with steroid-resistant nephrotic syndrome had increased ratios of circulating interferon- (IFN-) gamma-secreting Th1 cells and IL-4-secreting Th2 cells over Foxp3+ Treg cells when compared to 22 children with steroid-sensitive nephrotic syndrome in clinical remission and 14 healthy controls [20]. The gene discussed is IL4; the disease is nephrotic syndrome.