NOS2 and ischemic stroke: Figure 11 depicts how HLJDD and its three principal components affected the metabolic profiles and exhibited the therapeutic effects on ischemic stroke, which may be attributable to the amelioration of disordered metabolism, the upregulation of neuron autophagy, and the downregulation of oxidative stress and inflammatory response. Amelioration of neurological function in I/R by Ber and Bai may due to their induced increases in NF-κB, iNOS, and COX-2 protein expression.