On the other hand, men with MetS show decreased ICAM-1 levels and increased flow-mediated dilation after 46 g/day of freeze-dried grape polyphenol powder for 30 days [101], and green tea supplementation for eight weeks through infusion or powder did not significantly modify serum levels of adiponectin, CRP, IL-6, IL-1β, VCAM-1, ICAM-1, leptin, or leptin : adiponectin ratio [102] in both men and women with MetS. The gene discussed is IL1B; the disease is metabolic syndrome.