DNAX accessory molecule-1 is another NK-associated receptor that regulates Vγ9Vδ2-T cells, whereby blocking the interaction between DNAM-1 and its ligands, such as Nectin-like-5 and Nectin-2, could impair the cytotoxic capacity and IFN-γ production of Vγ9Vδ2-T cells against HCC cells (75). The gene discussed is CD226; the disease is hepatocellular carcinoma.