As demonstrated previously (10) in Hashimotos’ thyroiditis patients who were THAb negative prior to undergo diagnostic fine-needle aspiration biopsy (FNAC), the appearance in serum of THAb is preceded by the FNAC-elicited release of iodinated and heterologous moieties of thyroglobulin that were absent prior to FNAC. The gene discussed is TG; the disease is Hashimoto thyroiditis.