TP53 and B-cell non-Hodgkin lymphoma: Furthermore, Khandanpour et al. 21 reported a requirement for Gfi1 in the establishment and progression of murine B-cell lymphoma and T-cell acute lymphoblastic leukaemia driven by various genetic lesions, the ablation of Gfi1 leading to significant tumour regression and increased host survival in a p53-dependent manner30.