Similar to the observations of Hönes et al. 18 when considering the total AML cohort, analysis of the mutational status of our CN-AML subgroups revealed that FLT3-ITD and NPM1c mutations were more common in GFI1high samples, these being found in 59% (p = 0.0001) and 52% (p = 0.079) of patients, when compared to the GFI1low subgroup in which they were found in 11.2% and 29% of the patients, respectively (Table 1). This evidence concerns the gene FLT3 and acute myeloid leukemia.