Furthermore, Khandanpour et al. 21 reported a requirement for Gfi1 in the establishment and progression of murine B-cell lymphoma and T-cell acute lymphoblastic leukaemia driven by various genetic lesions, the ablation of Gfi1 leading to significant tumour regression and increased host survival in a p53-dependent manner30. This evidence concerns the gene TP53 and T-cell acute lymphoblastic leukemia.