In order to assess the significance of our observed correlation between GFI1 expression and the level of FLT3-ITD signature genes in FLT3-WT CN-AML, we next investigated whether manipulation of GFI1 expression in a human AML cell line would lead to corresponding changes in the expression of the FLT3-ITD signature genes. Here, GFI1 is linked to acute myeloid leukemia.