More importantly, in the attempt to validate the relevance of these findings, we observed that a number of the components of the FLT3-ITD molecular signature (IGFBP2, PRTN3, AK2, CTSG, ELANE and AZU1) were down regulated after siRNA-mediated silencing of GFI1 in Fujioka human AML cell line. Here, ELANE is linked to acute myeloid leukemia.