GFI1 and acute myeloid leukemia: Mutations in GFI1 that lead to a dominant-negative loss of function have been reported in a number of patients with congenital neutropenia16, whilst investigation of single nucleotide polymorphisms (SNP) associated with an increased predisposition towards AML led to the identification of a serine-asparagine substitution in the N-terminal region of GFI1 (GFI136N)17.