In addition, compared to the DNMT3B CC genotype, the association between the CT genotype and male infertility was not significantly different (adjusted OR, 1.25, 95% CI = 0.85–1.83, P = 0.255), but the TT homozygous genotype was associated with significantly decreased risk for male infertility with abnormal semen parameters (adjusted OR, 0.25, 95% CI = 0.06–0.94, P = 0.040). The gene discussed is DNMT3B; the disease is male infertility.