DNMT3B and male infertility: Under the recessive model of inheritance, the DNMT3B variant homozygote was associated with significantly decreased risk for male infertility with abnormal semen parameters (adjusted OR, 0.24, 95% CI = 0.06–0.90, P = 0.034), compared with other genotypes, after adjustment for age, BMI, smoking and drinking status in the multivariate logistic regression analysis (Table 2).