In our study, CD161+ cells co-expressing IL-17A and IFN-γ were enriched in the FRT of HIV uninfected women, and their proportion was associated with the luteal phase of the menstrual cycle but not cervical inflammation or bacterial infections, suggesting that in the FRT, this subset may not display inflammatory features but be part of the FRT normal environment. This evidence concerns the gene KLRB1 and bacterial infectious disease.