ACSL1 and cancer: This network comprises ACSL1 and ACSL4, members of the fatty acid activating enzymes acyl coA synthetases (ACSL), critical for lipid synthesis, modification and β-oxidation27; and the stearoyl-CoA desaturase (SCD), the main enzyme controlling the rate of saturated (SFA) vs unsaturated fatty acids (MUFA)28, crucial for cancer cells29.