We have shown that CRT could positively regulate VEGF protein expression and secretion levels in condition media of various NB cell lines10, and the evidence that blockage of VEGF signaling could suppress neuronal differentiation in CRT-overexpressed NB cells, indicates that VEGF could be involved in CRT-regulated neuronal differentiation and might predict a favorable tumor behavior in NB. Here, CALR is linked to neoplasm.