With respect to the dual oxidase enzymes, DUOX1 expression was associated with NADPH oxidase activity and the cell cycle, DNA replication, mismatch repair, and p53 signalling pathways, which were responsible for favourable effects on HCC survival, whereas DUOX2 expression was associated with attenuated cell proliferation, immunological pathways involving Fc-gamma receptor-mediated phagocytosis, and cell cycle regulation, which are associated with a better prognosis. The gene discussed is DUOX2; the disease is hepatocellular carcinoma.