To evaluate the impact of ENTPD2 on HCC tumorigenesis, we established ENTPD2 knockdown clones by short hairpin (sh) RNA approach in two HCC cell lines, MHCC97L (human) and Hepa1-6 (mouse), without altering the expression of other ENTPD family members (Supplementary Fig. 3). The gene discussed is ENTPD2; the disease is hepatocellular carcinoma.