TP53 and infection: Infection of telomerase-immortalized human primary endothelial cells by KSHV initially leads to a p53-dependent growth arrest, which may be triggered by the action of the KSHV viral D-cyclin homologue vCYC; expressed on its own, vCYC can induce a DNA damage response and p53-dependent growth arrest of vCYC-expressing cells [130].