High-throughput next-generation sequencing approaches identified some recurrent sites for integration in biopsies taken from HCC but at low incidence (i.e. telomerase reverse transcriptase (TERT), myeloid/lymphoid or mixed-lineage leukemia 4 (MLL4), cyclin E1 (CCNE1), neurotrophic tyrosine kinase receptor type 2 (NTRK2), interleukin-1 receptor-associated kinase-like 2 (IRAK2), mitogen-activated protein kinase 1 (MAPK1)) [43,44]. Here, CCNE1 is linked to hepatocellular carcinoma.