Of these, the uniquely high levels of LMP1 seen in EBV-positive HRS cells seem likely to be essential in the pathogenesis of HL, since LMP1 activates the NF-κB, JAK/STAT and PI3K cell signalling pathways, and induces transcriptional changes in GC B cells that are characteristic of HRS cells [73]. This evidence concerns the gene SOAT1 and Hodgkins lymphoma.