In Jurkat T cells lacking PEA‐15 expression, stimulation with interleukin 2 produced an enhanced proliferative response.20 In cancer, the role of PEA‐15 is complex and is partially related to phosphorylation status; however, it has been reported that decreased PEA‐15 expression in some cancer cells is related to increased proliferation and invasiveness.25, 26 Together, the studies cited and our own data indicate that PEA‐15 may be more generally involved in acting as a brake on cell proliferation in responses to several different cellular stresses. Here, PEA15 is linked to cancer.