Interestingly, we found that the synaptic scaffold protein Dmxl2 (haploinsufficiency causes Polyendocrine-polyneuropathy syndrome [Tata et al., 2014]) was reduced by ~70% (fold change: 0.28, p=0.00004) and studies in mice show heterozygous deletion of Dmxl2 in central neurons delayed the onset of puberty (Tata et al., 2014). The gene discussed is DMXL2; the disease is polyendocrine-polyneuropathy syndrome.