ERVW-1 and HIV infectious disease: However, this naturally occurring variant is rarely found in HIV-infected individuals because K425 Env may also induce potent bNAbs (due to a natural SOSIP/open-like structure) leading to immediate self-elimination. Placing this K425 in the Env expressed by VSV may result in a stable immunogen that elicits bNAbs and in the case of new HIV-1 exposure, would provide protection and eliminate the possibility of escape as observed in concurrent HIV infections.