ERVW-1 and infection: In support of this dogma, passive transfer of bNAb to macaques provided the best immune-related protection to SHIV infections to date [8, 9]. bNAbs have now been isolated from several HIV infected individuals at late stage infection and this topic has been reviewed by Ahmed et al. [25].  To elicit these all-mighty bNAbs, several research teams are using sequential vaccinations with mosaic Env vaccines or designer Env-based mimetics.