The findings that TMEM16A can promote migration and invasion of cancer cells agree with the reports showing that TMEM16A overexpression is associated with lymph node metastasis of ESCC [50] and increased risk of developing metastases in HNSCC [46], and correlates with poor prognosis in patients with breast cancer [42], gastric cancer [54], and HNSCC [45]. This evidence concerns the gene ANO1 and esophageal squamous cell carcinoma.