Although TMEM16A overexpression does not affect cell migration in HEK293 cells [94], TMEM16A promotes cell migration and invasion in various tumors such as HNSCC, hepatocellular carcinoma, lung cancer, glioblastoma, gastric cancer, pancreatic ductal adenocarcinoma, glioma, oral squamous cell carcinoma, and CRC [45, 46, 48, 51, 52, 54, 56, 92, 96, 97] (Table 1), as well as in non-tumor cells such as bronchial epithelial cells [98] and Ehrlich Lettre ascites (ELA) cells [99]. This evidence concerns the gene ANO1 and central nervous system cancer.