TMEM16A overexpression promotes cell proliferation in various cancers such as breast cancer, HNSCC, CRC, ESCC, glioma, lung cancer, hepatocellular carcinoma, and prostate cancer [42, 44, 48, 50–53, 56] (Table 1), and in non-tumor cells such as renal cyst-forming epithelial cells [90] and interstitial cells of Cajal [91]. Here, ANO1 is linked to esophageal squamous cell carcinoma.