Dixit et al. found that TMEM16A was overexpressed in HPV-negative HNSCC cells, and TMEM16A overexpression increased cell proliferation in HPV-negative HNSCC cells with hypomethylation of TMEM16A promoter, but not in HPV-positive HNSCC cells with TMEM16A promoter hypermethylation [75]. This evidence concerns the gene ANO1 and head and neck squamous cell carcinoma.