ANO1 and cancer: It is obvious that cancer cells with TMEM16A overexpression due to 11q13 gene amplification exhibit different intrinsic cellular environment from those TMEM16A-overexpressing cells without 11q13 gene amplification, since the 11q13 amplicon contains a variety of genes (CCND1, CTTN, FADD, FGF19) that regulate proliferation, apoptosis, and cell cycle [107].