Since the S970 residue in TMEM16A that is important for direct interaction between TMEM16A and radixin, and is required for TMEM16A’s effect on cell morphology and EMT [74], the activities of kinases or phosphatases that regulate the S970 phosphorylation may be different in different cancer cells, and thus may explain the different results of TMEM16A in cancer cell migration among different studies. Here, RDX is linked to cancer.