The incidence of symptomatic hypoglycemia in the omarigliptin group compared with the placebo group (22.6% vs. 19.7%) is consistent with previous observations of daily DPP-4 inhibitors, which can be associated with an increased risk of hypoglycemia when co-administered with drugs that are associated with hypoglycemia, such as insulin and sulfonylureas [12–14]. This evidence concerns the gene DPP4 and Hypoglycemia.