This list appeared to be strongly enriched (p-value = 10−12 after correction for multiple testing) in the genes of the signature DOANE_BREAST_CANCER_ESR1_UP “Genes up-regulated in breast cancer samples positive for ESR1 compared to the ESR1 negative tumors” from Molecular Signature Database [21] and several other specific to breast cancer gene signatures. This evidence concerns the gene ESR1 and breast cancer.