GRM5 and neoplasm: As shown in Table 4, there were considerable relationships between the detected hubs and events related to tumor progression such as cell cycle and DNA repair (TOP2A, HDAC1, HDAC2, BCL11A, BCL11B, POLA1, EHMT2, CEP72, GRM5, CAMK2A, GRAP2, and CACNA2D3), HIF-1α and VEGF production (PLCG and GRM5), chemoresistance (PLCG2 and PLCG1), chemotherapy outcomes (GRM5 and SPTAN1), and even autophagy (EHMT2).