The pathway enrichment analysis of PS gene set revealed high-affinity receptor for the immunoglobulin E (FcɛRI) SP, IFNγ SP, sphingolipid metabolism, Wnt/β-catenin SP in leukemia, signaling by growth factors (eg, ERBB4, PDFG, FGFRs, EGFR, and VEGFR2), CXCR4 SP, ionotropic glutamate receptor pathway, metabotropic glutamate receptor group I and III pathways, 5HT2 type receptor mediated SP, and histamine H1 receptor mediated SP (S1 Fig). The gene discussed is ERBB4; the disease is leukemia.