In contrast, HIF-1α-deficient inflammatory monocytes were significantly less parasitized at 12 and 24h in the absence of IFNγ (Fig 7A and S6C Fig); as for their HIF-1α-sufficient counterparts, the addition of IFNγ dramatically increased the rate of infection (Fig 6A), suggesting that HIF-1α is not involved in inducing regulatory monocytes. Here, IFNG is linked to infection.