TRIM24 and myelodysplastic syndrome: Since the growth inhibition curve and isobologram indicated a clear synergism in TF-1a erythroloid leukemic cells (Figures 1a and b and Supplementary Table 1) and cytarabine-resistant TF-1a/Ara-C cells (Table 1 and Supplementary Figures 1a and 3), we also evaluated the combination effects of T-3775440 with cytarabine, daunorubicine and azacitidine, which are used for the treatment of AML and/or MDS, in TF-1a cells (Figure 1c and Supplementary Figure 4).