We have shown previously that T-3775440 produces antileukemia effects by targeting a critical interaction between LSD1 and GFI1B transcription repressor in erythroid and megakaryoblastic leukemia cells.11 In the present study, GFI1B knockdown potentiated the antileukemia effects of pevonedistat, mimicking the synergistic interaction between T-3775440 and pevonedistat. Here, GFI1B is linked to adult acute megakaryoblastic leukemia.