We previously reported that T-3775440 leads to differentiation of AML cells and thereby induces cell growth arrest and apoptosis.11 Pevonedistat induces not only DNA rereplication-mediated genotoxic stress but also triggers the differentiation of AML cells.23 We therefore examined how cotreatment with these two agents affects transcriptional networks that regulate lineage specificity in TF-1a erythroid leukemia cells. Here, TRIM24 is linked to acute myeloid leukemia.