FLG and atopic eczema: The importance of FLG in the integrity of epidermal barrier function was stressed in previous studies, demonstrating that (1) loss-of-function mutation of the FLG gene is associated with the development of atopic dermatitis [10,11]; (2) Flg-deficient mice exhibit reduced epidermal barrier function with enhanced susceptibility to environmental sensitization [31]; and (3) upregulation of Flg is correlated with efficient barrier recovery of tape-stripped barrier-disrupted murine skin [32,33].