CTSD and glioblastoma: As illustrated in Figure 6B, we found that SH treatment for 24 h augmented the expression levels of LAMP-1 in the two cell lines in a dose-dependent manner; additionally, SH dose-dependently upregulated the expression of two major lysosomal cathepsins, cathepsin B and cathepsin D. To extend our findings, we confirmed that SH induced TFEB nuclear translocation in both human glioblastoma cell lines in a dose-dependent manner (Figure 6C).