Additionally, Cops3 has been implicated in keratinocyte interleukin signaling (Banda et al., 2005), which is interesting in light of the recent observation that loss of Dsg1 leads to an increase in inflammatory mediators in SAM syndrome, featuring severe dermatitis, multiple allergies, and metabolic wasting (Samuelov et al., 2013). Here, COPS3 is linked to dermatitis.