TNFSF12 and atherosclerosis: In macrophages, in turn, TNF-like weak inducer of apoptosis (TWEAK, Tnfsf12) and the receptor, fibroblast growth factor-inducible 14 (Fn14) promote ROS production and enhance nicotinamide adenine dinucleotide phosphate (NADPH) oxidase activity, which contributes to vascular damage and dysfunction in atherosclerosis (94).