Furthermore, direct links also exist between thrombin and HMGB1: HMGB1 is involved in a number of systemic vascular diseases [136, 137] and is also increased in stroke [105, 138], while both HMGB1 and thrombin are released in various neurologic conditions and HMGB1 promotes coagulation [139]. This evidence concerns the gene HMGB1 and stroke disorder.